• 9 czerwca, 2022

Wgląd w specyficzność wiązania peptydów na końcu C domeny PDZ neuronalnej syntazy tlenku azotu

Neuronowa syntaza tlenku azotu, w przeciwieństwie do jej śródbłonkowych i indukowalnych odpowiedników, wykazuje domenę PDZ (PSD-95/Dlg/ZO-1) zlokalizowaną na jej końcu N zaangażowaną w celowanie subkomórkowe. C-końce różnych białek komórkowych wstawiają się w bruzdę wiążącą tej domeny PDZ i określają subkomórkową dystrybucję neuronalnego NOS (nNOS). Mechanizmy molekularne leżące u podstaw tych interakcji są słabo poznane, ponieważ domena PDZ nNOS może najwyraźniej wykazywać specyficzność wiązania klasy I, klasy II i klasy III.

Ponadto ostatnio zasugerowano, że domena PDZ nNOS wiąże się z bardzo niskim powinowactwem z C-końcami białek docelowych i aby doszło do wiązania, musi zajść konieczna równoczesna interakcja boczna. Opisujemy tutaj, że domena PDZ nNOS może zachowywać się jak domena PDZ klasy III w dobrej wierze i wiązać się z sekwencjami C-końcowymi z resztami kwasowymi w pozycji P-2 z niskimi mikromolowymi stałymi wiązaniami. Wiązanie z sekwencjami C-końcowymi z resztą hydrofobową w pozycji P-2 oraz resztą kwasową w pozycji P-3 (klasa II) może również wystąpić, chociaż interakcje obejmujące reszty rozciągające się do pozycji P-7 pośredniczą w tego typu wiążący.

To rozwiązłe zachowanie rozciąga się również na jego powiązanie z sekwencjami klasy I, które muszą wykazywać resztę Glu w P-3 i resztę Thr w P-2 Za pomocą ukierunkowanej mutagenezy i spektroskopii NMR byliśmy w stanie zidentyfikować reszty zaangażowanych w każdy konkretny rodzaj wiązania i zracjonalizować mechanizmy stosowane do rozpoznawania partnerów wiążących.

Na koniec przeanalizowaliśmy związek o wysokim powinowactwie domeny PDZ nNOS z klaudyną-3 i klaudyną-14, dwoma ściśle połączonymi białkami błonowymi tetraspanowymi, które są niezbędnymi składnikami bariery parakomórkowej.

 

Wcześniejsze badania wykazały, że c-jun i neuronalna syntaza tlenku azotu (nNOS) są indukowane w uszkodzonych neuronach ruchowych, ale ich rola w śmierci neuronów ruchowych pozostaje niejasna.

  • Postawiliśmy hipotezę, że nNOS może być dalszym efektorem kinazy N-końcowej c-jun (JNK)/c-jun w śmierci neuronu ruchowego wywołanej oderwaniem. Tutaj odkryliśmy, że oderwanie korzenia ramiennego wywołało przejściowy wzrost aktywności JNK i odpowiednio trzy- i czterokrotny wzrost fosfo-c-jun i c-jun; jednak oderwanie korzenia ramiennego spowodowało zmniejszenie ekspresji białka nNOS od 4 godzin do 14 dni po urazie.
  • W 14 dni po urazie prawie wszystkie neurony ruchowe nNOS-dodatnie były zlokalizowane razem z neuronami ruchowymi fosfo-c-jun-dodatnimi w ipsilateralnych rogach brzusznych.
  • Inhibitor JNK SP600125, zastosowany bezpośrednio po urazie, powodował podwyższenie poziomu białka nNOS zarówno w uszkodzonych rdzeniach kręgowych, jak i neuronach ruchowych i powodował niewielkie złagodzenie śmierci neuronów ruchowych poprzez hamowanie fosforylacji c-jun 14 dni po urazie.
  • Nasze wyniki wykazały, że szlak transdukcji sygnału JNK/c-jun jest zaangażowany w oderwanie korzenia. Hamowanie fosforylacji c-jun zapobiega spadkowi poziomów nNOS poniżej poziomu wyjściowego w rdzeniu kręgowym i częściowo łagodzi śmierć neuronu ruchowego po wyrwaniu korzenia.
  • W związku z tym hamowanie fosforylacji c-jun lub zwiększanie poziomu białka nNOS w uszkodzonym rdzeniu kręgowym na wczesnym etapie może zostać wykorzystane w przyszłości jako strategie celów molekularnych w zapobieganiu degeneracji neuronów ruchowych podczas wybijania korzeni.

 

Ogon C-końcowy (CT) neuronalnej syntazy tlenku azotu (nNOS) jest elementem regulatorowym, który hamuje aktywność nNOS przy braku związanej kalmoduliny (CaM).

Struktura krystaliczna domeny reduktazy nNOS (nNOSr) (Garcin, ED, Bruns, CM, Lloyd, SJ, Hosfield, DJ, Tiso, M., Gachhui, R., Stuehr, DJ, Tainer, JA i Getzoff, ED (2004) J. Biol. Chem. 279, 37918-37927) ujawnili, w jaki sposób pierwsza połowa CT oddziałuje z nNOSr, a zatem dostarczyli szablonu do szczegółowych badań. Wygenerowaliśmy mutanty skrócone w nNOS i nNOSr, aby przetestować znaczenie 3 różnych regionów CT.

Wyeliminowanie końcowej połowy CT (wszystkich reszt od Ile1413 do Ser1429), która jest niewidoczna w strukturze kryształu, nie miało prawie żadnego wpływu na uwalnianie NADP+, redukcję flawiny, autooksydację flawiny, redukcję hemu, aktywność reduktazy lub aktywność syntezy NO, ale zapobiegał wzrostowi ekranowania FMN, który normalnie występuje w odpowiedzi na wiązanie NADPH.

Dodatkowe usunięcie alfa-helisy CT (reszty 1401 do 1412) znacząco zwiększyło szybkość uwalniania NADP+, autooksydację flawiny i aktywność oksydazy NADPH oraz spowodowało nadmierne odsłanianie kofaktora FMN. Efekty te były związane ze zwiększoną aktywnością reduktazy i nieznacznie zmniejszoną redukcją hemu i syntezą NO.

Dalsze usuwanie reszt za Gly1396 (pełne skrócenie CT) wzmocniło wyżej wymienione efekty, a ponadto zmieniło oddziaływanie NADP+ z FAD, złagodziło kinetyczną supresję redukcji flawiny i dalej zmniejszyło redukcję hemu i syntezę NO. Nasze wyniki pokazują, że CT wywiera zarówno wieloaspektowy, jak i regiospecyficzny wpływ na aktywność katalityczną i powiązane zachowania, a tym samym dostarcza nowego wglądu w mechanizmy regulujące katalizę nNOS.

Domeny PDZ to wielofunkcyjne motywy interakcji białek, które często wiążą się z C-końcem docelowych białek. Tlenek azotu (NO), endogenna cząsteczka sygnałowa, odgrywa kluczową rolę w funkcjonowaniu układu nerwowego, odpornościowego i sercowo-naczyniowego. Chociaż istnieje wiele funkcji fizjologicznych dla pochodzącego z neuronów NO, wytwarzanego głównie przez neuronalną syntazę NO (nNOS), nadmierna aktywność nNOS pośredniczy w uszkodzeniu mózgu w niedokrwieniu mózgu i w zwierzęcych modelach choroby Parkinsona.

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Human Nitric Oxide Synthase 1, Neuronal / nNOS (NOS1) ELISA Kit

abx570102-96tests Abbexa 96 tests 801.6 EUR

Sheep Nitric Oxide Synthase 1, Neuronal / nNOS (NOS1) ELISA Kit

abx364404-96tests Abbexa 96 tests 1111.2 EUR

Mouse Nitric Oxide Synthase 1, Neuronal / nNOS (NOS1) ELISA Kit

abx055268-96tests Abbexa 96 tests 801.6 EUR

Human Nitric Oxide Synthase 1, Neuronal / nNOS (NOS1) ELISA Kit

abx253515-96tests Abbexa 96 tests 801.6 EUR

Mouse Nitric Oxide Synthase 1, Neuronal / nNOS (NOS1) ELISA Kit

abx254292-96tests Abbexa 96 tests 801.6 EUR

Human Nitric Oxide Synthase 1, Neuronal / nNOS (NOS1) ELISA Kit

20-abx152535 Abbexa
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human NOS1/nNOS(Nitric Oxide Synthase 1, Neuronal) ELISA Kit

RE1411H-48wells Reed Biotech 48 wells 116.55 EUR

Human NOS1/nNOS(Nitric Oxide Synthase 1, Neuronal) ELISA Kit

RE1411H-96wells Reed Biotech 96 wells 161.55 EUR

Mouse NOS1/nNOS(Nitric Oxide Synthase 1, Neuronal) ELISA Kit

RE1411M-48wells Reed Biotech 48 wells 116.55 EUR

Mouse NOS1/nNOS(Nitric Oxide Synthase 1, Neuronal) ELISA Kit

RE1411M-96wells Reed Biotech 96 wells 161.55 EUR

Rabbit Nitric Oxide Synthase 1, Neuronal / nNOS (NOS1) ELISA Kit

abx362730-96tests Abbexa 96 tests 990 EUR

Monkey Nitric Oxide Synthase 1, Neuronal / nNOS (NOS1) ELISA Kit

abx358861-96tests Abbexa 96 tests 990 EUR

CLIA kit for Rat NOS1/nNOS (Nitric Oxide Synthase 1, Neuronal)

E-CL-R0746 Elabscience Biotech 1 plate of 96 wells 700.8 EUR

Chicken Nitric Oxide Synthase 1, Neuronal / nNOS (NOS1) ELISA Kit

abx356455-96tests Abbexa 96 tests 990 EUR

ELISA kit for Rat NOS1/nNOS (Nitric Oxide Synthase 1, Neuronal)

E-EL-R1438 Elabscience Biotech 1 plate of 96 wells 640.8 EUR

CLIA kit for Mouse NOS1/nNOS (Nitric Oxide Synthase 1, Neuronal)

E-CL-M0697 Elabscience Biotech 1 plate of 96 wells 700.8 EUR

CLIA kit for Human NOS1/nNOS (Nitric Oxide Synthase 1, Neuronal)

E-CL-H0537 Elabscience Biotech 1 plate of 96 wells 700.8 EUR

ELISA kit for Mouse NOS1/nNOS (Nitric Oxide Synthase 1, Neuronal)

E-EL-M1281 Elabscience Biotech 1 plate of 96 wells 640.8 EUR

ELISA kit for Human NOS1/nNOS (Nitric Oxide Synthase 1, Neuronal)

E-EL-H0742 Elabscience Biotech 1 plate of 96 wells 640.8 EUR

NOS1/nNOS ELISA Kit| Mouse Nitric Oxide Synthase 1, Neuronal ELI

EF013784 Lifescience Market 96 Tests 826.8 EUR

NOS1/nNOS ELISA Kit| Rat Nitric Oxide Synthase 1, Neuronal ELISA

EF017083 Lifescience Market 96 Tests 826.8 EUR

Guinea pig Nitric Oxide Synthase 1, Neuronal / nNOS (NOS1) ELISA Kit

abx357551-96tests Abbexa 96 tests 990 EUR

Rat Neuronal Nitric Oxide Synthase ELISA kit

E02N0069-192T BlueGene 192 tests 1524 EUR

Rat Neuronal Nitric Oxide Synthase ELISA kit

E02N0069-48 BlueGene 1 plate of 48 wells 624 EUR

Rat Neuronal Nitric Oxide Synthase ELISA kit

E02N0069-96 BlueGene 1 plate of 96 wells 822 EUR

Dog Neuronal Nitric Oxide Synthase ELISA kit

E08N0069-192T BlueGene 192 tests 1524 EUR

Dog Neuronal Nitric Oxide Synthase ELISA kit

E08N0069-48 BlueGene 1 plate of 48 wells 624 EUR

Dog Neuronal Nitric Oxide Synthase ELISA kit

E08N0069-96 BlueGene 1 plate of 96 wells 822 EUR

Pig Neuronal Nitric Oxide Synthase ELISA kit

E07N0069-192T BlueGene 192 tests 1524 EUR

Pig Neuronal Nitric Oxide Synthase ELISA kit

E07N0069-48 BlueGene 1 plate of 48 wells 624 EUR

Pig Neuronal Nitric Oxide Synthase ELISA kit

E07N0069-96 BlueGene 1 plate of 96 wells 822 EUR

Rat Neuronal Nitric Oxide Synthase ELISA kit

E01A14954 BlueGene 96T 700 EUR

Goat Neuronal Nitric Oxide Synthase ELISA kit

E01A49860 BlueGene 96T 700 EUR

Goat Neuronal Nitric Oxide Synthase ELISA kit

E06N0069-192T BlueGene 192 tests 1524 EUR

Goat Neuronal Nitric Oxide Synthase ELISA kit

E06N0069-48 BlueGene 1 plate of 48 wells 624 EUR

Goat Neuronal Nitric Oxide Synthase ELISA kit

E06N0069-96 BlueGene 1 plate of 96 wells 822 EUR

Sheep Neuronal Nitric Oxide Synthase ELISA kit

E01A102154 BlueGene 96T 700 EUR

Human Neuronal Nitric Oxide Synthase ELISA kit

E01A6207 BlueGene 96T 700 EUR

Mouse Neuronal Nitric Oxide Synthase ELISA kit

E01A23701 BlueGene 96T 700 EUR

Mouse Neuronal Nitric Oxide Synthase ELISA kit

E03N0069-192T BlueGene 192 tests 1524 EUR

Mouse Neuronal Nitric Oxide Synthase ELISA kit

E03N0069-48 BlueGene 1 plate of 48 wells 624 EUR

Mouse Neuronal Nitric Oxide Synthase ELISA kit

E03N0069-96 BlueGene 1 plate of 96 wells 822 EUR

Human Neuronal Nitric Oxide Synthase ELISA kit

E01N0069-192T BlueGene 192 tests 1524 EUR

Human Neuronal Nitric Oxide Synthase ELISA kit

E01N0069-48 BlueGene 1 plate of 48 wells 624 EUR

Human Neuronal Nitric Oxide Synthase ELISA kit

E01N0069-96 BlueGene 1 plate of 96 wells 822 EUR

Rabbit Neuronal Nitric Oxide Synthase ELISA kit

E01A32425 BlueGene 96T 700 EUR

Monkey Neuronal Nitric Oxide Synthase ELISA kit

E01A76007 BlueGene 96T 700 EUR

Bovine Neuronal Nitric Oxide Synthase ELISA kit

E01A84727 BlueGene 96T 700 EUR

Canine Neuronal Nitric Oxide Synthase ELISA kit

E01A67290 BlueGene 96T 700 EUR

Monkey Neuronal Nitric Oxide Synthase ELISA kit

E09N0069-192T BlueGene 192 tests 1524 EUR

Monkey Neuronal Nitric Oxide Synthase ELISA kit

E09N0069-48 BlueGene 1 plate of 48 wells 624 EUR

Monkey Neuronal Nitric Oxide Synthase ELISA kit

E09N0069-96 BlueGene 1 plate of 96 wells 822 EUR

Rabbit Neuronal Nitric Oxide Synthase ELISA kit

E04N0069-192T BlueGene 192 tests 1524 EUR

Rabbit Neuronal Nitric Oxide Synthase ELISA kit

E04N0069-48 BlueGene 1 plate of 48 wells 624 EUR

Rabbit Neuronal Nitric Oxide Synthase ELISA kit

E04N0069-96 BlueGene 1 plate of 96 wells 822 EUR

Porcine Neuronal Nitric Oxide Synthase ELISA kit

E01A58578 BlueGene 96T 700 EUR

Chicken Neuronal Nitric Oxide Synthase ELISA kit

E01A93441 BlueGene 96T 700 EUR

Guinea Pig Neuronal Nitric Oxide Synthase ELISA kit

E01A41140 BlueGene 96T 700 EUR

Guinea pig Neuronal Nitric Oxide Synthase ELISA kit

E05N0069-192T BlueGene 192 tests 1524 EUR

Guinea pig Neuronal Nitric Oxide Synthase ELISA kit

E05N0069-48 BlueGene 1 plate of 48 wells 624 EUR

Guinea pig Neuronal Nitric Oxide Synthase ELISA kit

E05N0069-96 BlueGene 1 plate of 96 wells 822 EUR

Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody

20-abx129333 Abbexa
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  • 100 ug
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  • 200 ug
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Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody

20-abx173833 Abbexa
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  • 100 ug
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  • 20 ug
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Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody

20-abx103472 Abbexa
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  • 100 ug
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Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody

20-abx103473 Abbexa
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  • 100 ug
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Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody

20-abx103474 Abbexa
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  • 100 ug
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Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody

20-abx103475 Abbexa
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  • 100 ug
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Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody

20-abx103476 Abbexa
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  • 100 ug
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Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody

20-abx103477 Abbexa
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  • 100 ug
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Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody

20-abx103478 Abbexa
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  • 100 ug
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Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

AP79849 SAB 1mg 2640 EUR

Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

AP81351 SAB 1mg 2640 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43055-100ug Biomatik Corporation 100ug 554.4 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43055-1mg Biomatik Corporation 1mg 2457 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43055-50ug Biomatik Corporation 50ug 445.5 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43056-100ug Biomatik Corporation 100ug 578.6 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43056-1mg Biomatik Corporation 1mg 2566.2 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43056-50ug Biomatik Corporation 50ug 465.3 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43057-100ug Biomatik Corporation 100ug 556.6 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43057-1mg Biomatik Corporation 1mg 2467.4 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43057-50ug Biomatik Corporation 50ug 447.7 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43058-100ug Biomatik Corporation 100ug 556.6 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43058-1mg Biomatik Corporation 1mg 2467.4 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43058-50ug Biomatik Corporation 50ug 447.7 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43059-100ug Biomatik Corporation 100ug 578.6 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43059-1mg Biomatik Corporation 1mg 2566.2 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43059-50ug Biomatik Corporation 50ug 465.3 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43060-100ug Biomatik Corporation 100ug 556.6 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43060-1mg Biomatik Corporation 1mg 2467.4 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43060-50ug Biomatik Corporation 50ug 447.7 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43061-100ug Biomatik Corporation 100ug 556.6 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43061-1mg Biomatik Corporation 1mg 2467.4 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43061-50ug Biomatik Corporation 50ug 447.7 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43062-100ug Biomatik Corporation 100ug 578.6 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43062-1mg Biomatik Corporation 1mg 2566.2 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPU43062-50ug Biomatik Corporation 50ug 465.3 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPA815Hu01 Cloud-Clone 10ug 180 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

4-RPA815Hu01 Cloud-Clone
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  • 100 ug
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  • 200 ug
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  • 5 mg

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPA815Mu01 Cloud-Clone 10ug 181 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

4-RPA815Mu01 Cloud-Clone
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  • 100 ug
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  • 200 ug
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  • 5 mg

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPA815Mu02 Cloud-Clone 10ug 181 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

4-RPA815Mu02 Cloud-Clone
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  • 100 ug
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  • 200 ug
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  • 50ug
  • 5 mg

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPA815Mu03 Cloud-Clone 10ug 181 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

4-RPA815Mu03 Cloud-Clone
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  • 100 ug
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  • 200 ug
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  • 5 mg

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPA815Mu04 Cloud-Clone 10ug 181 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

4-RPA815Mu04 Cloud-Clone
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  • 100 ug
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  • 200 ug
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  • 5 mg

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPA815Ra01 Cloud-Clone 10ug 188 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

4-RPA815Ra01 Cloud-Clone
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  • 100 ug
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  • 200 ug
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  • 5 mg

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPA815Ra02 Cloud-Clone 10ug 188 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

4-RPA815Ra02 Cloud-Clone
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  • 100 ug
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  • 200 ug
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  • 5 mg

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

RPA815Ra03 Cloud-Clone 10ug 188 EUR

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1)

4-RPA815Ra03 Cloud-Clone
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  • 100 ug
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  • 5 mg

Human Neuronal Nitric Oxide Synthase 1(NOS1) ELISA Kit

SL2612Hu Sunlong 96 Tests 468 EUR

Rat Nitric Oxide Synthase 1, Neuronal (NOS1) Protein

20-abx068296 Abbexa
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  • 100 ug
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Rat Nitric Oxide Synthase 1, Neuronal (NOS1) Protein

20-abx068299 Abbexa
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  • 100 ug
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Rat Nitric Oxide Synthase 1, Neuronal (NOS1) Protein

20-abx068302 Abbexa
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  • 100 ug
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Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody Pair

20-abx370344 Abbexa
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  • 10 × 96 tests
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Human Nitric Oxide Synthase 1, Neuronal (NOS1) Protein

20-abx068295 Abbexa
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  • 100 ug
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Mouse Nitric Oxide Synthase 1, Neuronal (NOS1) Protein

20-abx068297 Abbexa
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  • 100 ug
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Mouse Nitric Oxide Synthase 1, Neuronal (NOS1) Protein

20-abx068298 Abbexa
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  • 100 ug
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Mouse Nitric Oxide Synthase 1, Neuronal (NOS1) Protein

20-abx068300 Abbexa
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  • 100 ug
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Mouse Nitric Oxide Synthase 1, Neuronal (NOS1) Protein

20-abx068301 Abbexa
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  • 100 ug
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CLIA Kit for Nitric Oxide Synthase 1, Neuronal (NOS1)

SCA815Hu Cloud-Clone 96Т 840 EUR

Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody (Biotin)

20-abx274315 Abbexa
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  • 100 ug
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Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody (Biotin)

20-abx272743 Abbexa
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  • 100 ug
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Nitric Oxide Synthase 1, Neuronal (NOS1) Antibody (Biotin)

20-abx273214 Abbexa
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  • 100 ug
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Rat Nitric Oxide Synthase 1, Neuronal (NOS1) ELISA Kit

DLR-NOS1-Ra DL Develop 96T 454 EUR

Rat Nitric Oxide Synthase 1, Neuronal (NOS1) ELISA Kit

DLR-NOS1-Ra-48T DL Develop 48T 609.6 EUR

Rat Nitric Oxide Synthase 1, Neuronal (NOS1) ELISA Kit

DLR-NOS1-Ra-96T DL Develop 96T 793.2 EUR

Rat NOS1(Nitric Oxide Synthase 1, Neuronal) ELISA Kit

ELK1620-48T ELK Biotech 48T Ask for price

Rat NOS1(Nitric Oxide Synthase 1, Neuronal) ELISA Kit

ELK1620-96T ELK Biotech 96T Ask for price

Rat Nitric Oxide Synthase 1, Neuronal (NOS1) ELISA Kit

EKN47417-48T Biomatik Corporation 48T 370.02 EUR

Rat Nitric Oxide Synthase 1, Neuronal (NOS1) ELISA Kit

EKN47417-5x96T Biomatik Corporation 5x96T 2510.85 EUR

Rat Nitric Oxide Synthase 1, Neuronal (NOS1) ELISA Kit

EKN47417-96T Biomatik Corporation 96T 528.6 EUR

Rat Nitric Oxide Synthase 1, Neuronal (NOS1) ELISA Kit

EKU06306-48T Biomatik Corporation 48T 542.78 EUR

Rat Nitric Oxide Synthase 1, Neuronal (NOS1) ELISA Kit

EKU06306-5x96T Biomatik Corporation 5x96T 3683.15 EUR

Dlatego też subkomórkowa lokalizacja aktywności nNOS musi być ściśle regulowana. Aby określić ligandy domeny PDZ nNOS, przeszukaliśmy 13 miliardów różnych peptydów i odkryliśmy, że domena nNOS-PDZ wiąże się ściśle z peptydami kończącymi się Asp-X-Val. Różni się to od jedynego znanego konsensusu (Thr/Ser)-X-Val, który oddziałuje z domenami PDZ z PSD-95. W preferencji dla Asp w pozycji peptydu -2 pośredniczy Tyr-77 z nNOS. Podstawienie Y77D78 do H77E78 zmienia specyficzność wiązania z Asp-X-Val na Thr-X-Val. Kierując się konsensusem Asp-X-Val, zidentyfikowano kandydujące białka oddziałujące z nNOS, w tym receptory glutaminianu i melatoniny. Nasze wyniki pokazują, że domeny PDZ mają wyraźną specyficzność wiązania peptydów.

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