Skuteczność szczepionkowa rekombinowanej szczepionki przeciw chorobie Mareka 301B/1 Ekspresja interleukiny kurzej-15
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Szczepionka przeciwko chorobie Mareka (MD) nie zapewnia sterylizującej odporności, która zapobiega późniejszej replikacji i wydalaniu wirusa MD (MDV) u zaszczepionych ptaków. Postawiono hipotezę, że odporność komórkowa ma kluczowe znaczenie dla kontrolowania replikacji wirusa u kurcząt , ponieważ MDV występuje u gospodarza w formach związanych z komórką. Aby poprawić skuteczność szczepionki MD, w szczególności odporność komórkową, skonstruowaliśmy rekombinowaną v301B/1-IL-15, szczep 301B/1 szczepionkowy MDV serotypu 2 eksprymujący kurzą interleukinę (IL-15), cytokinę, która promuje T- proliferacja komórek i wzmacnia odpowiedzi komórek T.
Zbadaliśmy skuteczność szczepionki v301B/1-IL-15 podanej jako biwalentna szczepionka MD w połączeniu z herpeswirusem indyków (HVT) przeciwko bardzo zjadliwej prowokacji MDV. Ekspresja IL-15 nie wpływała na stabilność wirusa i wzrost rekombinowanej v301B/1-IL-15.
Jednakże skuteczność ochronna v301B/1-IL-15 nie różniła się znacząco od tej v301B/1, rodzicielskiego wirusa użytego do skonstruowania v301B/1-IL-15. Wydalanie wirusa prowokującego było nieznacznie zmniejszone w dniu 21 (16 dni po prowokacji) w grupie zaszczepionej v301B/1-IL-15 plus HVT, bez statystycznie istotnej różnicy w porównaniu z grupą zaszczepioną v301B/1 plus HVT, a atrofia grasicy była zaobserwowano, że jest mniej dotkliwy w grupie zaszczepionej v301B/1-IL-15 plus HVT. Ogólnie rzecz biorąc, ochrona v301B/1-IL-15 nie różniła się od v301B/1 przed bardzo zjadliwą prowokacją MDV, ale nie ma wpływu na skuteczność dwuwalentnej szczepionki MD.
Eficacia de una vacuna recombinante contra la enfermedad de Marek 301B/1 que expresa a la interleucina-15 del pollo.
La vacunación contra la enfermedad de Marek (con las siglas en inglés MD) no proporciona inmunidad esteriante que evite la posteriori replikación y diseminación de este virus (MDV) en las aves vacunadas.
- Se plantea la hipótesis de que la inmunidad mediada por células es fundamentalne para kontroli replikacji wirusa w pollos porque el virus e Marek istnieje w formach asociadas a células en el huésped. Para mejorar la eficacia de la vacuna de Marek, specificmente la inmunidad mediada por células, se construyó un el virus recombinante v301B/1-IL-15, que es una cepa vacunal del serotipo 2, 301B/1, que expresa el gene de la interleucina-15 de pollo (IL-15) , que es una citocina que promueve la proliferación celular de células T y mejora la respuesta de las células T.
- Zapoznaj się z badaniem skuteczności odkurzacza v301B/1-IL-15 podawaną w związku z odkurzaczem dwuwartościowym przeciwko enfermedadowi Marka w połączeniu z wirusem opryszczki wirusowej (HVT) przeciwko desafío muy virulento. Wyrażenie IL-15 nie miało wpływu na ustalenie wirusa i replikację zrekombinowanego wirusa v301B/1-IL-15. Sin embargo, la eficacia protectora de v301B/1-IL-15 no fue significativamente diferente de la obtenida con el virus v301B/1, que es el virus progenitor utilizado para construir v301B/1-IL-15.
- La diseminación del virus de desafío se redujo ligeramente en el día 21 (16 dni después del desafío) en el group vacunado con v301B/1-IL-15 más HVT, sin diferencias estadísticamente significativas conspecto má con v301B y la atrofia del timo se observó que era menos severa en el grupo vacunado con v301B/1-IL-15 más HVT. Ogólnie rzecz biorąc, ochrona konferencji z v301B/1-IL-15 nie ma szczególnego znaczenia na temat konferencji w wersji v301B/1 przeciwko ekspozycji wirusa Marka na wirus wirulentny, bez wpływu na siano z powodu skuteczności wirusa Marka biwalentnego.
Do zwalczania kokcydiozy u kur potrzebne są tanie, łatwe w produkcji szczepionki doustne, aby zmniejszyć wpływ tej choroby na dobrostan i wyniki ekonomiczne.
Drożdże Saccharomyces cerevisiae eksprymujące trzy antygeny Eimeria tenella zostały opracowane i dostarczone kurczętom w postaci zabitych termicznie, liofilizowanych pełnych drożdżowych szczepionek doustnych w czterech oddzielnych badaniach. Po szczepieniu replikacja E. tenella została zmniejszona po prowokacji niską dawką (250 oocyst) u kur niosek Hy-Line Brown (p<0,01). Podobnie, ocena zmian w kątnicy została zmniejszona u kurcząt Hy-Line Brown niosek zaszczepionych mieszaniną S. cerevisiae wyrażającą EtAMA1, EtIMP1 i EtMIC3 po prowokacji na poziomie patogennym (4000 oocyst E. tenella ; p<0,01).
Średni przyrost masy ciała po prowokacji 15 000 oocyst E. tenella był znacząco zwiększony u zaszczepionych kurcząt brojlerów Cobb500 w porównaniu z kontrolami szczepionymi pozornie (p<0,01). Tak więc inaktywowane rekombinowane szczepionki drożdżowe oferują opłacalne i skalowalne możliwości kontroli kokcydiozy, co ma znaczenie dla produkcji brojlerów i kurcząt hodowanych w krajach o niskim i średnim dochodzie (LMIC).
Podtyp H5 wysoce zjadliwy wirus ptasiej grypy (HPAIV) był wprowadzany do Korei Południowej co 2 lub 3 lata przez dzikie migrujące ptactwo wodne, powodując niszczycielskie szkody w przemyśle drobiarskim. Chociaż większość szkód i strat ekonomicznych spowodowanych przez HPAIV koncentruje się na nioskach kurcząt, wiadomo, że kaczki domowe odgrywają główną rolę w przenoszeniu z gospodarstwa na gospodarstwo.
Jednak większość badań nad szczepionką HPAIV na drobiu przeprowadzono z użyciem inaktywowanych szczepionek emulsją olejową. W tym badaniu opracowaliśmy żywą rekombinowaną szczepionkę wektorową wirusa choroby Newcastle (NDV) przeciwko H5 HPAIV (rK148/ES2-HA) przy użyciu wcześniej ustalonego szczepu szczepionkowego NDV (K148/08) wyizolowanego z dzikiej kaczki krzyżówki. Skuteczność szczepionki podawanej drogą oczno-nosową lub w postaci sprayu oceniano wobec śmiertelnego zakażenia H5 HPAIV u kaczek domowych i kurcząt. Inokulacja oczno-nosowa rK148/ES2-HA u kurcząt i kaczek wywołała miana przeciwciał przeciwko HPAIV już 1 lub 2 tygodnie po pojedynczej dawce szczepienia, podczas gdy szczepienie natryskowe u kaczek wywołało przeciwciała przeciwko HPAIV po szczepieniu przypominającym.
Kurczęta i kaczki szczepione rK148/ES2-HA wykazywały wysokie wskaźniki przeżywalności i niskie wydalanie wirusa po prowokacji H5N6 HPAIV. Łącznie szczepienie rK148/ES2-HA zapobiegało śmiertelnej infekcji i zmniejszało wydalanie wirusa zarówno u kur, jak i kaczek. Szczepionka opracowana w tym badaniu może być użyteczna w hamowaniu wydalania wirusa w epidemiach H5 HPAIV, z łatwością aplikacji szczepionki i szybkim początkiem odporności.
W ostatnich dziesięcioleciach choroby związane z adenowirusem drobiu (FAdV) stały się coraz większym problemem dla przemysłu drobiarskiego na całym świecie.
Przebadano eksperymentalnie różne strategie immunizacji przeciwko FAdV, ze szczególnym uwzględnieniem szczepionek podjednostkowych przeciwko zespołowi zapalenia wątroby i wodosierdzia (HHS), wywoływanemu przez serotyp 4 FAdV i wtrętowemu zapaleniu wątroby (IBH), wywoływanemu przez serotypy 2, 8a, 8b i 11 .
W tym badaniu rozszerzyliśmy naszą innowacyjną koncepcję rekombinowanych chimerycznych białek włóknistych, aby zaprojektować nową chimerę łączącą epitopy z dwóch różnych serotypów, FAdV-4 i -11, i zbadaliśmy jej skuteczność w jednoczesnej ochronie kurczaków przed HHS i IBH. Kurczęta wolne od określonych patogenów zaszczepiono nowym rekombinowanym włóknem chimerycznym, a następnie poddano prowokacji szczepem wywołującym HHS lub IBH. Ptaki szczepione/prowokowane wykazywały zmniejszenie objawów klinicznych, ograniczoną hepatomegalię i niższe poziomy AST w porównaniu z odpowiednimi kontrolami prowokowanymi.
Ponadto szczepionka zapobiegała atrofii narządów limfoidalnych dotkniętych HHS, takich jak grasica i torebka Fabrycjusza, a miano wirusa w narządach docelowych zostało znacznie zmniejszone. Ochrona kliniczna była związana z wysokimi poziomami przeciwciał przed prowokacją mierzonymi na płytkach ELISA pokrytych antygenem szczepionkowym. Co ciekawe, rozwój przeciwciał neutralizujących był ograniczony przeciwko FAdV-11 i nieobecny przeciwko FAdV-4, co wskazuje, że ochrona zapewniana przez taki antygen może być powiązana z różnymi szlakami immunizacji.
Immunization Grade Chick Type II Collagen, 10 mg, lyophilized |
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20052 | Chondrex | 2 mg/ml x 0.5 ml | 374 EUR |
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Immunization Grade Human Type XI Collagen, 1 mg, lyophilized |
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Immunization Grade Bovine Type I Collagen, 10 mg, lyophilized |
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1305 | Chondrex | 1 mg | 303 EUR |
Immunization Grade Bovine Type IX Collagen, 5 mg, lyophilized |
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1072 | Chondrex | 5 mg | 331 EUR |
Immunization Grade Bovine Type XI Collagen, 5 mg, lyophilized |
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1082 | Chondrex | 5 mg | 271 EUR |
Immunization Grade Bovine Type III Collagen, 1 mg, lyophilized |
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1302 | Chondrex | 1 mg | 147 EUR |
Immunization Grade Porcine Type IX Collagen, 5 mg, lyophilized |
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1073 | Chondrex | 5 mg | 331 EUR |
Immunization Grade Porcine Type XI Collagen, 5 mg, lyophilized |
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1083 | Chondrex | 5 mg | 271 EUR |
Immunization Grade Human Amnion Type V Collagen, 1 mg, lyophilized |
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1095 | Chondrex | 1 mg | 347 EUR |
Immunization Grade Bovine Amnion Type V Collagen, 1 mg, lyophilized |
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1092 | Chondrex | 1 mg | 303 EUR |
Immunization Grade Human Placenta Type V Collagen, 1 mg, lyophilized |
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10951 | Chondrex | 1 mg | 347 EUR |
cBSA *Optimized for Maximum Immunization Response* |
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5600 | AAT Bioquest | 10 mg | 227 EUR |
cBSA *Optimized for Maximum Immunization Response* |
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5600-10mg | AAT Bioquest | 10 mg | 222 EUR |
hBSA *Optimized for Maximum Immunization Response* |
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cOVA *Optimized for Maximum Immunization Response* |
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5605 | AAT Bioquest | 10 mg | 227 EUR |
cOVA *Optimized for Maximum Immunization Response* |
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5605-10mg | AAT Bioquest | 10 mg | 222 EUR |
hOVA *Optimized for Maximum Immunization Response* |
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5606 | AAT Bioquest | 10 mg | 227 EUR |
hOVA *Optimized for Maximum Immunization Response* |
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5606-10mg | AAT Bioquest | 10 mg | 222 EUR |
Custom Production of Monoclonal antibodies (immunization, ELISA Kit, fusion, screening, Cloning of up to 3 clones) |
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MAB-1 | Alpha Diagnostics | 1 | 12483.6 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) |
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MBS645296-02mL | MyBiosource | 0.2mL | 695 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) |
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CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (AP) |
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MBS6284050-02mL | MyBiosource | 0.2mL | 980 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (AP) |
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MBS6284050-5x02mL | MyBiosource | 5x0.2mL | 4250 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (PE) |
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MBS6284060-02mL | MyBiosource | 0.2mL | 980 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (PE) |
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MBS6284060-5x02mL | MyBiosource | 5x0.2mL | 4250 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (APC) |
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MBS6284051-02mL | MyBiosource | 0.2mL | 980 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (APC) |
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MBS6284051-5x02mL | MyBiosource | 5x0.2mL | 4250 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (Biotin) |
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MBS6284052-02mL | MyBiosource | 0.2mL | 980 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (Biotin) |
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MBS6284052-5x02mL | MyBiosource | 5x0.2mL | 4250 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (FITC) |
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MBS6284053-02mL | MyBiosource | 0.2mL | 980 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (FITC) |
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MBS6284053-5x02mL | MyBiosource | 5x0.2mL | 4250 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (MaxLight 405) |
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MBS6284055-01mL | MyBiosource | 0.1mL | 980 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (MaxLight 405) |
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MBS6284055-5x01mL | MyBiosource | 5x0.1mL | 4250 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (MaxLight 490) |
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MBS6284056-01mL | MyBiosource | 0.1mL | 980 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (MaxLight 490) |
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MBS6284056-5x01mL | MyBiosource | 5x0.1mL | 4250 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (MaxLight 550) |
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MBS6284057-01mL | MyBiosource | 0.1mL | 980 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (MaxLight 550) |
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MBS6284057-5x01mL | MyBiosource | 5x0.1mL | 4250 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (MaxLight 650) |
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MBS6284058-01mL | MyBiosource | 0.1mL | 980 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (MaxLight 650) |
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MBS6284058-5x01mL | MyBiosource | 5x0.1mL | 4250 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (MaxLight 750) |
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MBS6284059-01mL | MyBiosource | 0.1mL | 980 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (MaxLight 750) |
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MBS6284059-5x01mL | MyBiosource | 5x0.1mL | 4250 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (Azide free) (HRP) |
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MBS6284054-02mL | MyBiosource | 0.2mL | 980 EUR |
CDCP1, CT (CDCP1, TRASK, CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, CD318) (Azide free) (HRP) |
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MBS6284054-5x02mL | MyBiosource | 5x0.2mL | 4250 EUR |
CDCP1, isoform 1, CT (CUB domain containing protein 1, CD318, Membrane glycoprotein gp140, SIMA135, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, TRASK, UNQ2486/PRO5773) |
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MBS622157-01mg | MyBiosource | 0.1mg | 655 EUR |
CDCP1, isoform 1, CT (CUB domain containing protein 1, CD318, Membrane glycoprotein gp140, SIMA135, Subtractive immunization M plus HEp3-associated 135kD protein, Transmembrane and associated with src kinases, TRASK, UNQ2486/PRO5773) |
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MBS622157-5x01mg | MyBiosource | 5x0.1mg | 2800 EUR |
CDCP1, CT (CUB Domain Containing Protein 1, CD318, CD318 Antigen, FLJ13772, FLJ22375, FLJ22969, Membrane Glycoprotein gp140, MGC31813, Subtractive Immunization M Plus HEp3-associated 135kD Protein, Transmembrane and Associated with Src Kinases, TRASK) |
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MBS620721-01mg | MyBiosource | 0.1mg | 810 EUR |
CDCP1, CT (CUB Domain Containing Protein 1, CD318, CD318 Antigen, FLJ13772, FLJ22375, FLJ22969, Membrane Glycoprotein gp140, MGC31813, Subtractive Immunization M Plus HEp3-associated 135kD Protein, Transmembrane and Associated with Src Kinases, TRASK) |
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MBS620721-5x01mg | MyBiosource | 5x0.1mg | 3500 EUR |
T-Cell Grade Chick Type II Collagen, 0.5 mg, lyophilized |
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2021 | Chondrex | 0.5 mg | 195 EUR |
Lysozyme From Chicken Eggs (Food Grade) |
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LYZ-65E | Creative BioMart | 1g | 39.2 EUR |
Innovative Grade US Origin Chicken Bile |
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Innovative Grade US Origin Chicken Bile |
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Innovative Grade US Origin Chicken Head |
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Innovative Grade US Origin Chicken Aorta |
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Innovative Grade US Origin Chicken Aorta |
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IGCHAOPT1 | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Aorta |
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IGCHAOPT2 | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Aorta |
|||
IGCHAOST1 | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Aorta |
|||
IGCHAOST2 | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Aorta |
|||
IGCHAOZT1 | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Aorta |
|||
IGCHAOZT2 | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Heart |
|||
IGCHHTF | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Heart |
|||
IGCHHTP | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Heart |
|||
IGCHHTS | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Heart |
|||
IGCHHTZ | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Lungs |
|||
IGCHLGF | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Lungs |
|||
IGCHLGP | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Lungs |
|||
IGCHLGS | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Lungs |
|||
IGCHLGZ | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Liver |
|||
IGCHLRF1000GM | Innovative research | each | 254 EUR |
Innovative Grade US Origin Chicken Liver |
|||
IGCHLRF300GM | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Liver |
|||
IGCHLRP1000GM | Innovative research | each | 330 EUR |
Innovative Grade US Origin Chicken Liver |
|||
IGCHLRP300GM | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Liver |
|||
IGCHLRS1000GM | Innovative research | each | 330 EUR |
Innovative Grade US Origin Chicken Liver |
|||
IGCHLRS300GM | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Liver |
|||
IGCHLRZ1000GM | Innovative research | each | 254 EUR |
Innovative Grade US Origin Chicken Liver |
|||
IGCHLRZ300GM | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Serum |
|||
IGCHSER100ML | Innovative research | each | 298 EUR |
Innovative Grade US Origin Chicken Serum |
|||
IGCHSER50ML | Innovative research | each | 185 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLAK2E100ML | Innovative research | each | 298 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLAK2E50ML | Innovative research | each | 185 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLAK3E100ML | Innovative research | each | 298 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLAK3E50ML | Innovative research | each | 185 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLALIH100ML | Innovative research | each | 298 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLALIH50ML | Innovative research | each | 185 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLANAC100ML | Innovative research | each | 298 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLANAC50ML | Innovative research | each | 185 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLANAE100ML | Innovative research | each | 298 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLANAE50ML | Innovative research | each | 185 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLANAH100ML | Innovative research | each | 298 EUR |
Innovative Grade US Origin Chicken Plasma |
|||
IGCHPLANAH50ML | Innovative research | each | 185 EUR |
Innovative Grade US Origin Chicken Gizzard |
|||
IGCHGZF | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Gizzard |
|||
IGCHGZP | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Gizzard |
|||
IGCHGZS | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Gizzard |
|||
IGCHGZZ | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Parotid |
|||
IGCHPTDF | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Parotid |
|||
IGCHPTDP | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Parotid |
|||
IGCHPTDS | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Parotid |
|||
IGCHPTDZ | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Sternum |
|||
IGCHSRF | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Sternum |
|||
IGCHSRP | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Sternum |
|||
IGCHSRS | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Sternum |
|||
IGCHSRZ | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Trachea |
|||
IGCHTCAF | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Trachea |
|||
IGCHTCAFT1 | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Trachea |
|||
IGCHTCAP | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Trachea |
|||
IGCHTCAPT1 | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Trachea |
|||
IGCHTCAS | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Trachea |
|||
IGCHTCAST1 | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Trachea |
|||
IGCHTCAZ | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Trachea |
|||
IGCHTCAZT1 | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Pancreas |
|||
IGCHPCSF | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Pancreas |
|||
IGCHPCSP | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Pancreas |
|||
IGCHPCSS | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Pancreas |
|||
IGCHPCSZ | Innovative research | each | 133 EUR |
Filamin Standard Grade From Chicken Gizzard |
|||
GWB-955E5F | GenWay Biotech | 0.25 mg | Ask for price |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBASV100ML | Innovative research | each | 231 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBASV500ML | Innovative research | each | 700 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBASV50ML | Innovative research | each | 163 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBK2E500ML | Innovative research | each | 722 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBK2E50ML | Innovative research | each | 163 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBK3E100ML | Innovative research | each | 220 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBK3E500ML | Innovative research | each | 722 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBK3E50ML | Innovative research | each | 163 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBLIH100ML | Innovative research | each | 231 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBLIH500ML | Innovative research | each | 700 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBLIH50ML | Innovative research | each | 170 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBNAC100ML | Innovative research | each | 220 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBNAC500ML | Innovative research | each | 722 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBNAC50ML | Innovative research | each | 163 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBNAE100ML | Innovative research | each | 220 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBNAE500ML | Innovative research | each | 722 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBNAE50ML | Innovative research | each | 163 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBNAH100ML | Innovative research | each | 220 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBNAH500ML | Innovative research | each | 722 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCHWBNAH50ML | Innovative research | each | 163 EUR |
Innovative Grade US Origin Chicken Whole Blood |
|||
IGCNHWBK2E100ML | Innovative research | each | 220 EUR |
Collagen Type II, chicken |
|||
MBS397124-01mL | MyBiosource | 0.1mL | 630 EUR |
Collagen Type II, chicken |
|||
MBS397124-5x01mL | MyBiosource | 5x0.1mL | 2680 EUR |
Innovative Grade US Origin Chicken Gland Pituitary |
|||
IGCHGLPTF | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Gland Pituitary |
|||
IGCHGLPTP | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Gland Pituitary |
|||
IGCHGLPTS | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Gland Pituitary |
|||
IGCHGLPTZ | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Reproductive Tract |
|||
IGCHRPTCTF | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Reproductive Tract |
|||
IGCHRPTCTP | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Reproductive Tract |
|||
IGCHRPTCTS | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Reproductive Tract |
|||
IGCHRPTCTZ | Innovative research | each | 133 EUR |
Native Chicken Collagen Type II |
|||
NATE-1165 | Creative BioMart | 1 kg | 263.2 EUR |
Innovative Grade US Origin Chicken Intestine Small Ileum Only |
|||
IGCHINTF | Innovative research | each | 133 EUR |
Innovative Grade US Origin Chicken Intestine Small Ileum Only |
|||
IGCHINTP | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Intestine Small Ileum Only |
|||
IGCHINTS | Innovative research | each | 210 EUR |
Innovative Grade US Origin Chicken Intestine Small Ileum Only |
|||
IGCHINTZ | Innovative research | each | 133 EUR |
Chicken egg ovalbumin protein (ELISA Kit, antigen, allergy grade) |
|||
OVA15-N-1000 | Alpha Diagnostics | 1 g | 489.6 EUR |
Chicken Collagen Type II (COL- II) ELISA Kit |
|||
SL0173Ch | Sunlong | - | Ask for price |
T-Cell Grade Chick Type I Collagen, 0.5 mg, lyophilized |
|||
1051 | Chondrex | 0.5 mg | 100 EUR |
Chicken Collagen Type II ELISA kit |
|||
E01A89648 | BlueGene | 96T | 700 EUR |
Chicken Collagen Type II ELISA Kit |
|||
MBS016577-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 6725 EUR |
Chicken Collagen Type II ELISA Kit |
|||
MBS016577-48StripWells | MyBiosource | 48-Strip-Wells | 550 EUR |
Chicken Collagen Type II ELISA Kit |
|||
MBS016577-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 3420 EUR |
Chicken Collagen Type II ELISA Kit |
|||
MBS016577-96StripWells | MyBiosource | 96-Strip-Wells | 765 EUR |
Chicken Collagen Type II ELISA Kit |
|||
MBS743899-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 5685 EUR |
Chicken Collagen Type II ELISA Kit |
|||
MBS743899-48StripWells | MyBiosource | 48-Strip-Wells | 485 EUR |
Chicken Collagen Type II ELISA Kit |
|||
MBS743899-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 3020 EUR |
Chicken Collagen Type II ELISA Kit |
|||
MBS743899-96StripWells | MyBiosource | 96-Strip-Wells | 690 EUR |
Chicken Procollagen Type II ELISA kit |
|||
E01A94043 | BlueGene | 96T | 700 EUR |
Chicken Collagenase, Type II ELISA kit |
|||
E01A89445 | BlueGene | 96T | 700 EUR |
Chicken Collagenase Type II ELISA Kit |
|||
NSL0929Ch | Sunlong | 1024 T | 528 EUR |
Chicken Procollagen Type II ELISA Kit |
|||
MBS7209996-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 5685 EUR |
Chicken Procollagen Type II ELISA Kit |
|||
MBS7209996-48StripWells | MyBiosource | 48-Strip-Wells | 485 EUR |
Chicken Procollagen Type II ELISA Kit |
|||
MBS7209996-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 3020 EUR |
Chicken Procollagen Type II ELISA Kit |
|||
MBS7209996-96StripWells | MyBiosource | 96-Strip-Wells | 690 EUR |
Chicken Collagenase, Type II ELISA Kit |
|||
MBS748548-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 5685 EUR |
Chicken Collagenase, Type II ELISA Kit |
|||
MBS748548-48StripWells | MyBiosource | 48-Strip-Wells | 485 EUR |
Chicken Collagenase, Type II ELISA Kit |
|||
MBS748548-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 3020 EUR |
Chicken Collagenase, Type II ELISA Kit |
|||
MBS748548-96StripWells | MyBiosource | 96-Strip-Wells | 690 EUR |
Chicken Collagenase Type II ELISA Kit |
|||
MBS265539-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 3545 EUR |
Chicken Collagenase Type II ELISA Kit |
|||
MBS265539-48StripWells | MyBiosource | 48-Strip-Wells | 310 EUR |
Chicken Collagenase Type II ELISA Kit |
|||
MBS265539-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 1940 EUR |
Chicken Collagenase Type II ELISA Kit |
|||
MBS265539-96StripWells | MyBiosource | 96-Strip-Wells | 475 EUR |
Chicken Collagenase Type II ELISA Kit |
|||
EIA05506Ch | Enlibio | each | 520 EUR |
Chicken Type II Collagen Autoantibody ELISA Kit |
|||
MBS034954-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Chicken egg ovalbumin protein (OVA, >98% pure, Low endotoxin, antigen grade) |
|||
OVA17-N-10 | Alpha Diagnostics | 10 mg | 270 EUR |
Chicken egg ovalbumin protein (OVA, >98% pure, Low endotoxin, antigen grade) |
|||
OVA17-N-100 | Alpha Diagnostics | 100 mg | 826.8 EUR |
Chicken Type II iodothyronine deiodinase ELISA kit |
|||
E01A91317 | BlueGene | 96T | 700 EUR |
Chicken Type II Iodothyronine Deiodinase ELISA Kit |
|||
MBS026096-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Chicken Type II iodothyronine deiodinase ELISA Kit |
|||
MBS746671-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 5685 EUR |
Chicken Type II iodothyronine deiodinase ELISA Kit |
|||
MBS746671-48StripWells | MyBiosource | 48-Strip-Wells | 485 EUR |
Chicken Type II iodothyronine deiodinase ELISA Kit |
|||
MBS746671-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 3020 EUR |
Chicken Type II iodothyronine deiodinase ELISA Kit |
|||
MBS746671-96StripWells | MyBiosource | 96-Strip-Wells | 690 EUR |
Chicken Type II iodothyronine deiodinase ELISA Kit |
|||
MBS2880946-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 4630 EUR |
Chicken Type II iodothyronine deiodinase ELISA Kit |
|||
MBS2880946-48StripWells | MyBiosource | 48-Strip-Wells | 440 EUR |
Chicken Type II iodothyronine deiodinase ELISA Kit |
|||
MBS2880946-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 2480 EUR |
Chicken Type II iodothyronine deiodinase ELISA Kit |
|||
MBS2880946-96StripWells | MyBiosource | 96-Strip-Wells | 580 EUR |
Chicken Type-1 angiotensin II receptor ELISA Kit |
|||
MBS2880795-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 4630 EUR |
Chicken Type-1 angiotensin II receptor ELISA Kit |
|||
MBS2880795-48StripWells | MyBiosource | 48-Strip-Wells | 440 EUR |
Chicken Type-1 angiotensin II receptor ELISA Kit |
|||
MBS2880795-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 2480 EUR |
Chicken Type-1 angiotensin II receptor ELISA Kit |
|||
MBS2880795-96StripWells | MyBiosource | 96-Strip-Wells | 580 EUR |
Chicken COL2(Collagen Type II) ELISA Kit |
|||
ELK8629-48T | ELK Biotech | 48T | Ask for price |
Chicken COL2(Collagen Type II) ELISA Kit |
|||
ELK8629-96T | ELK Biotech | 96T | Ask for price |
Chicken Collagen Type II (COL2)ELISA Kit |
|||
NSL1226Ch | Sunlong | 1321 T | 528 EUR |
Chicken COL2 (Collagen Type II) ELISA Kit |
|||
MBS8807553-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 3130 EUR |
Chicken COL2 (Collagen Type II) ELISA Kit |
|||
MBS8807553-48StripWells | MyBiosource | 48-Strip-Wells | 415 EUR |
Chicken COL2 (Collagen Type II) ELISA Kit |
|||
MBS8807553-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 1710 EUR |
Chicken COL2 (Collagen Type II) ELISA Kit |
|||
MBS8807553-96StripWells | MyBiosource | 96-Strip-Wells | 545 EUR |
Chicken Collagen Type II (COL2) ELISA Kit |
|||
MBS263652-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 3545 EUR |
Chicken Collagen Type II (COL2) ELISA Kit |
|||
MBS263652-48StripWells | MyBiosource | 48-Strip-Wells | 310 EUR |
Chicken Collagen Type II (COL2) ELISA Kit |
|||
MBS263652-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 1940 EUR |
Chicken Collagen Type II (COL2) ELISA Kit |
|||
MBS263652-96StripWells | MyBiosource | 96-Strip-Wells | 475 EUR |
Chicken Collagen Type II (COL2) ELISA Kit |
|||
EIA05499Ch | Enlibio | each | 520 EUR |
Chicken Paired Immunoglobulin-Like Type 2 Receptor Alpha (PILRA) ELISA Kit |
|||
MBS9905301-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Chicken Collagen Type II Antibody ELISA kit |
|||
E01A91232 | BlueGene | 96T | 700 EUR |
Chicken Collagen Type II Cleavage ELISA kit |
|||
E01A89372 | BlueGene | 96T | 700 EUR |
Chicken Collagen Type II Cleavage ELISA Kit |
|||
MBS756119-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 5685 EUR |
Chicken Collagen Type II Cleavage ELISA Kit |
|||
MBS756119-48StripWells | MyBiosource | 48-Strip-Wells | 485 EUR |
Chicken Collagen Type II Cleavage ELISA Kit |
|||
MBS756119-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 3020 EUR |
Chicken Collagen Type II Cleavage ELISA Kit |
|||
MBS756119-96StripWells | MyBiosource | 96-Strip-Wells | 690 EUR |
Chicken type II collagen helical peptide ELISA Kit |
|||
E01A92449 | BlueGene | 96T | 700 EUR |
Recombinant Chicken Type-1 angiotensin II receptor (AGTR1) |
|||
MBS7007438-002mg | MyBiosource | 0.02mg | 1675 EUR |
Recombinant Chicken Type-1 angiotensin II receptor (AGTR1) |
|||
MBS7007438-01mg | MyBiosource | 0.1mg | 2635 EUR |
Recombinant Chicken Type-1 angiotensin II receptor (AGTR1) |
|||
MBS7007438-5x01mg | MyBiosource | 5x0.1mg | 11810 EUR |
Recombinant Chicken Type-1 angiotensin II receptor (AGTR1) |
|||
MBS957435-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Type II Collagen (isolate from chicken cartilage) |
|||
COS-T2C1 | Creative BioMart | 1kg | 174.4 EUR |
Chicken Type II Iodothyronine Deiodinase (DIO2) ELISA Kit |
|||
abx513383-96tests | Abbexa | 96 tests | 1093.2 EUR |
Chicken Type II iodothyronine deiodinase,DIO2 ELISA KIT |
|||
ELI-02062c | Nova Lifetech | 96tests | 796 EUR |
Chicken Type II iodothyronine deiodinase (DIO2) ELISA Kit |
|||
RK07012 | Abclonal | 96T | 280 EUR |
Chicken Deiodinase, Iodothyronine, Type II ELISA Kit |
|||
MBS059256-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Chicken Collagen Type II Alpha 1 ELISA kit |
|||
E01A89434 | BlueGene | 96T | 700 EUR |
Chicken Collagen Type II Alpha 1 ELISA Kit |
|||
MBS004963-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Chicken Collagen Type II Alpha 1 ELISA Kit |
|||
MBS743416-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 5685 EUR |
Chicken Collagen Type II Alpha 1 ELISA Kit |
|||
MBS743416-48StripWells | MyBiosource | 48-Strip-Wells | 485 EUR |
Chicken Collagen Type II Alpha 1 ELISA Kit |
|||
MBS743416-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 3020 EUR |
×
Podsumowując, udowodniliśmy, że koncepcja szczepionek z błonnikiem chimerowym może być rozszerzona poza granice gatunków wirusowych i stanowi pierwszą jednoskładnikową szczepionkę podjednostkową FAdV zapewniającą kompleksową ochronę przed różnymi chorobami związanymi z FAdV.
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